Drug Like Properties

Filename: drug-like-properties.pdf
ISBN: 9780128013229
Release Date: 2015-12-17
Number of pages: 580
Author: Li Di
Publisher: Academic Press

Download and read online Drug Like Properties in PDF and EPUB Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods


Evolution re F hrung

Filename: evolution-re-f-hrung.pdf
ISBN: 9783834990457
Release Date: 2007-12-04
Number of pages: 264
Author: Michael Alznauer
Publisher: Springer-Verlag

Download and read online Evolution re F hrung in PDF and EPUB Dieses Buch gibt konzentrierte Einblicke in die wirklich grundlegenden Erfolgsbausteine der Führungsaufgabe. Es vermittelt eine außergewöhnliche Fülle von Anregungen für konstruktive Führungsarbeit. Eine originelle, klar strukturierte und nützliche Lektüre. Besonders innovativ sind Einblicke in die Methode des Management-Profilings.


Using Mass Spectrometry for Drug Metabolism Studies Second Edition

Filename: using-mass-spectrometry-for-drug-metabolism-studies-second-edition.pdf
ISBN: 1420092219
Release Date: 2009-11-03
Number of pages: 451
Author: Walter A. Korfmacher
Publisher: CRC Press

Download and read online Using Mass Spectrometry for Drug Metabolism Studies Second Edition in PDF and EPUB The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices. The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART. With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.


Developing Solid Oral Dosage Forms

Filename: developing-solid-oral-dosage-forms.pdf
ISBN: 9780128026373
Release Date: 2016-11-08
Number of pages: 1176
Author: Yihong Qiu
Publisher: Academic Press

Download and read online Developing Solid Oral Dosage Forms in PDF and EPUB Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more. Written and edited by an international team of leading experts with experience and knowledge across industry, academia, and regulatory settings Includes new chapters covering the pharmaceutical applications of surface phenomenon, predictive biopharmaceutics and pharmacokinetics, the development of formulations for drug discovery support, and much more Presents new case studies throughout, and a section completely devoted to regulatory aspects, including global product regulation and international perspectives


ADMET for Medicinal Chemists

Filename: admet-for-medicinal-chemists.pdf
ISBN: 0470922818
Release Date: 2011-02-15
Number of pages: 512
Author: Katya Tsaioun
Publisher: John Wiley & Sons

Download and read online ADMET for Medicinal Chemists in PDF and EPUB This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.


Hayes Principles and Methods of Toxicology Sixth Edition

Filename: hayes-principles-and-methods-of-toxicology-sixth-edition.pdf
ISBN: 9781842145364
Release Date: 2014-10-10
Number of pages: 2184
Author: A. Wallace Hayes
Publisher: CRC Press

Download and read online Hayes Principles and Methods of Toxicology Sixth Edition in PDF and EPUB Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.


Biochemical Pharmacology

Filename: biochemical-pharmacology.pdf
ISBN: 9781118230336
Release Date: 2012-04-09
Number of pages: 428
Author: Michael Palmer
Publisher: John Wiley & Sons

Download and read online Biochemical Pharmacology in PDF and EPUB An integrated approach to the study of drug action mechanisms Biochemical Pharmacology is a concise and contemporary textbook on the principles of drug action. It discusses representative drugs by example to explore the range of biochemical targets and mechanisms. The book explains some of the experiments that tell us how drugs work, and it outlines the physiological and pathological context that make those action mechanisms therapeutically useful. Biochemical Pharmacology is intended primarily for students in biology and biochemistry at the advanced undergraduate or graduate levels. For classroom use, the illustrations from the book are separately available as PowerPoint slides. It is written in a conversational, vivid style that readily encourages students to explore this important area of medical science. Biochemical Pharmacology can also serve as an introduction for professionals in biosciences, as well as in pharmaceutical and health sciences. Complete with numerous figures throughout the text, which are also available separately as PowerPoint slides, Biochemical Pharmacology: Explains the role of pharmacodynamics, pharmacokinetics, and drug metabolism in drug action Provides representative examples from the pharmacology of cell excitation, hormones, nitric oxide, chemotherapy, and others Examines emerging applications of ribonucleic acids as drugs and drug targets Discusses what researchers need to know about the problems of drug distribution, elimination, and toxicity Biochemical Pharmacology is an important resource for anyone wishing to gain an in-depth understanding of drug action mechanisms and extremely useful for researchers wishing to explore some of the unanswered questions .


Umweltanalytik mit Spektrometrie und Chromatographie

Filename: umweltanalytik-mit-spektrometrie-und-chromatographie.pdf
ISBN: 9783527660629
Release Date: 2012-03-06
Number of pages: 312
Author: Hubert Hein
Publisher: John Wiley & Sons

Download and read online Umweltanalytik mit Spektrometrie und Chromatographie in PDF and EPUB Der bew?hrte Wegweiser f?r erfolgreiche Umweltanalytik, jetzt in einer vollst?ndig ?berarbeiteten und erweiterten Neuauflage! Die neue, dritte Auflage behandelt insbesondere auch Aspekte der Wirtschaftlichkeit sowie in einem eigenen Kapitel die Methoden der Vor-Ort-Analytik. Jeder Laborleiter kann sich mit diesem einzigartigen Handbuch kompakt, aktuell und gezielt ?ber den Stand des Labormanagements sowie der anerkannten spektrometrischen und chromatographischen Methoden informieren. Die Aufgaben des Laborleiters werden von der Planung der Laborr?ume bis zur Dokumentation der Analysen beschrieben. Dazu z?hlen insbesondere die Themen - Umweltgesetzgebung - Probenahme und Probenvorbereitung - Bezugsquellen f?r anerkannte Analysenmethoden Besonderes Merkmal: Durch das Griffregister hat der Benutzer leichten Zugang zu ?bersichtlichen Tabellen. Sie sind nach Parameter, Umweltkompartiment und Aggregatzustand gegliedert und erm?glichen das rasche Auffinden einer anerkannten Analysenmethode. Aus Rezensionen der vorigen Auflagen: "Genau auf die Bed?rfnisse der Laborleiter zugeschnitten" Fachinformationszentrum Karlsruhe "Hubert Hein und Wolfgang Kunze haben ein neuartiges Buch geschrieben. Was die Verfasser in besonderem Ma?e auszeichnet: Sie wissen aus eigener T?tigkeit und vielfacher Erfahrung, wor?ber sie schreiben. Es handelt sich um eine Monographie, die im Fachschrifttum nicht mehr wegzudenken sein wird." Deutsche Gew?sserkundliche Mitteilungen



The Organic Chemistry of Drug Design and Drug Action

Filename: the-organic-chemistry-of-drug-design-and-drug-action.pdf
ISBN: 9780123820310
Release Date: 2014-03-29
Number of pages: 536
Author: Richard B. Silverman
Publisher: Academic Press

Download and read online The Organic Chemistry of Drug Design and Drug Action in PDF and EPUB The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates


Pharmazeutische Mikrobiologie

Filename: pharmazeutische-mikrobiologie.pdf
ISBN: 9783527810505
Release Date: 2017-06-30
Number of pages: 440
Author: Michael Rieth
Publisher: John Wiley & Sons

Download and read online Pharmazeutische Mikrobiologie in PDF and EPUB In seinem Buch zur pharmazeutischen Mikrobiologie geht Michael Rieth, promovierter Mikrobiologe mit langjï¿1⁄2hriger Erfahrung in mikrobiologischer Qualitï¿1⁄2tsprï¿1⁄2fung in der pharmazeutischen Industrie, auf alle Aspekte dieses fï¿1⁄2r die Pharmaproduktion unentbehrlichen Gebietes ein. Schwerpunkte sind Methoden der Qualitï¿1⁄2tskontrolle, das Umgebungsmonitoring in der Pharma- und Chemieproduktion sowie die Betriebshygiene. Der Fokus liegt auf bakteriologischen Verfahren einschlieï¿1⁄2lich der mikrobiologischen Schnellmethoden; daneben werden aber auch Zellkulturmethoden und Tiermodelle behandelt. Fï¿1⁄2r die zweite Auflage wurden unter anderem die Themen "Low Endotoxin Recovery" und Maskierung / Demaskierung von Endotoxinen neu aufgenommen. Wo immer mï¿1⁄2glich, werden die Bezï¿1⁄2ge zu den neuesten Ausgaben der europï¿1⁄2ischen und US-amerikanischen Arzneibï¿1⁄2cher hergestellt.


Taschenatlas Pharmakologie

Filename: taschenatlas-pharmakologie.pdf
ISBN: 9783131516572
Release Date: 2014-12-17
Number of pages: 416
Author: Lutz Hein
Publisher: Georg Thieme Verlag

Download and read online Taschenatlas Pharmakologie in PDF and EPUB Wirkt sofort Dieser Taschenatlas hilft. Beschwerden der Verwirrung und Überforderung werden sofort gemildert und weichen dem Gefühl des Verstehens und Begreifens. Die Wirkstoffe Visualisierung und Kompaktheit sind in großen Mengen aktiv. - Über 170 brillante Infografiken illustrieren die Pharmakologie und erleichtern Dir den Zugang zu pharmakologischen Sachverhalten - Die kompakten Lerneinheiten eignen sich als Ergänzung zu einem Lehrbuch, zum Vertiefen und Wiederholen. - Alle relevanten Informationen zu Wirkstoffgruppen kannst Du rasch und gut verständlich nachlesen. - Das sinnvolle arzneimitteltherapeutische Vorgehen bei wichtigen Erkrankungen kompakt und auf dem aktuellen Stand. - Arzneimittelkonvertierungslisten helfen Dir auf der Suche nach dem Wirkstoff- oder Handelsnamen. - Dank Daumenregister und Farbleitsystem kannst Du Dich schnell orientieren. - Du verstehst Zusammenhänge und schaust über den ein oder anderen Tellerrand



Klinisch toxikologische Analytik

Filename: klinisch-toxikologische-analytik.pdf
ISBN: 352730164X
Release Date: 2002-10-04
Number of pages: 673
Author: Wolf Rüdiger Külpmann
Publisher: Wiley-VCH

Download and read online Klinisch toxikologische Analytik in PDF and EPUB Der klinisch-toxikologische Analytiker findet in diesem Buch genaue Arbeitsvorschriften für die Durchführung der Laboratoriumsdiagnostik bei Intoxikationen und Abusus. Im Falle von Pharmaka eignen sich die Verfahren auch zur Kontrolle der Therapie (Therapeutic Drug Monitoring). Ärzte, wie z.B. Intensivmediziner, Internisten, Psychiater und Kinderärzte erhalten wichtige Hinweise auf die analytischen Möglichkeiten zur Erkennung von Vergiftungen und Abusus sowie zur medizinischen Bewertung der Analysenergebnisse. Die Autoren beschreiben jeweils zunächst detailliert die Durchführung des Verfahrens, so daß ohne weiteren Rückgriff auf Originalpublikationen die Analysen vorgenommen werden können. Die Verfahren, u.a. Immunoassays, Hochleistungsflüssigkeitschromatographie, Gaschromatographie-Massenspektrometrie, sind von den Autoren zum großen Teil selbst entwickelt worden, in jedem Fall aber ausführlich auf ihre Zuverlässigkeit und Praktikabilität überprüft worden. An die Beschreibung der Analysenverfahren schließt sich die medizinische Beurteilung und klinische Interpretation an. Es werden die wichtigsten Symptome der jeweiligen Vergif-tung einschließlich der klinisch-chemischen Befunde sowie die pharma-kokineti-schen Daten (z.B. toxische Konzentration, Eliminationshalbwertzeit) angegeben. Die Autoren sind Ärzte für Laboratoriumsmedizin, Klinische Chemiker, Rechtsmediziner und Pharmakologen aus der Arbeitsgruppe für Klinisch-toxikologische Analytik der Deutschen Ge-sellschaft für Klinische Chemie und aus der Gesellschaft für Toxikologische und Forensische Chemie.


Arzneimittelgeschichte

Filename: arzneimittelgeschichte.pdf
ISBN: STANFORD:36105114721520
Release Date: 2005
Number of pages: 282
Author: Wolf-Dieter Müller-Jahncke
Publisher:

Download and read online Arzneimittelgeschichte in PDF and EPUB Spannend wie ein Krimi! Arzneimittelgeschichte - ein alter Zopf? Keineswegs, denn auch unsere heutigen modernen Arzneimittel sind nicht wie Phönix aus der Asche entstanden, sondern wurden - teils auf abenteuerlichen Umwegen - Schritt für Schritt entwickelt. Zwei Pharmaziehistoriker und ein Industrieapotheker nehmen den Leser mit auf eine Reise durch die Geschichte der Medikamente: . Von Therapiekonzepten und Arzneiformen der Antike bis heute, . von iatromagischen Arzneimitteln bis zur Isolierung des Morphins, und . von der zufälligen Entdeckung des Penicillins bis zur systematischen Arzneimittelentwicklung auf Basis der modernen Rezeptorpharmakologie. Weitere Etappen sind die überarbeiteten und aktualisierten Kapitel zur Geschichte der modernen synthetischen Arzneimittel - von den Analgetika bis zu den Zytostatika. Pharmazie- und Medizinhistoriker, Apotheker und Ärzte, Studenten der Pharmazie und Medizin sowie alle anderen, die sich für Arzneimittel und ihre Geschichte interessieren, werden in diesem Buch spannende Entdeckungen machen.